An inhibitor of ELOVL1
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ELOVL1-22

Item No. 36142

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-2-phenyl-4-[6-[[cis-3-(1H-pyrazol-1-yl)cyclobutyl]oxy]-4-pyrimidinyl]-morpholine
CAS Number
2761063-99-2
Molecular Formula
C21H23N5O2
Formula Weight
377.4
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 25 mg/ml
λmax
253 nm
SMILES
N1(C2=NC=NC(O[C@H]3C[C@@H](N4C=CC=N4)C3)=C2)C[C@H](C5=CC=CC=C5)OCC1
InChi Code
InChI=1S/C21H23N5O2/c1-2-5-16(6-3-1)19-14-25(9-10-27-19)20-13-21(23-15-22-20)28-18-11-17(12-18)26-8-4-7-24-26/h1-8,13,15,17-19H,9-12,14H2/t17-,18+,19-/m1/s1
InChi Key
JXGFJBHPOCYADP-CEXWTWQISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $109

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    5 mg

    $464

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    10 mg

    $818

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    25 mg

    $1,362

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    Product Description

    ELOVL1-22 is an inhibitor of ELOVL fatty acid elongase 1 (ELOVL1).1 It reduces lysohexacosanoylphosphatidylcholine (LPC(C26:0)) synthesis in HEK293 cells (IC50 = 400 pM), a marker of ELOVL1 inhibition, and is selective for ELOVL1 over ELOVL4, -6, and -7 (IC50s = >50 µM for all), as well as a panel of 34 receptors at 10 µM. ELOVL1-22 (1-32 mg/kg) reduces blood and CNS levels of LPC(C26:0) in an Abcd1-/- mouse model of adrenoleukodystrophy (ALD), a neurodegenerative disease characterized by rapid inflammatory demyelination of the CNS.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boyd, M.J., Collier, P.N., Clark, M.P., et al. Discovery of novel, orally bioavailable pyrimidine ether-based inhibitors of ELOVL1. J. Med. Chem. 64(24), 17777-17794 (2021).