A triterpene with anticancer and senescence modifying activities
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Epifriedelanol

Item No. 36148

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,4β,5β,8α,9β,10α,13α,14β)-5,9,13-trimethyl-4,25,26-trinoroleanan-3-ol
CAS Number
16844-71-6
Synonyms
  • Friedelan-3β-ol
  • β-Friedelinol
  • epi-Friedelanol
  • Longan Triterpane A
Molecular Formula
C30H52O
Formula Weight
428.7
Purity
≥85%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleDMF: Slightly solubleDMSO: Slightly soluble
SMILES
C[C@@]12[C@]([C@@]3([H])[C@@](CC1)(CCC(C)(C3)C)C)(CC[C@@]4([C@]2([H])CC[C@]5([C@@]4([H])CC[C@@H]([C@@H]5C)O)C)C)C
InChi Code
InChI=1S/C30H52O/c1-20-21(31)9-10-22-27(20,5)12-11-23-28(22,6)16-18-30(8)24-19-25(2,3)13-14-26(24,4)15-17-29(23,30)7/h20-24,31H,9-19H2,1-8H3/t20-,21-,22+,23-,24+,26+,27+,28-,29+,30-/m0/s1
InChi Key
XCDQFROEGGNAER-PFOIMGGJSA-N
Origin
Plant/Aster tataricus L. f.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Product Description

    Epifriedelanol is a triterpene that has been found in U. davidiana root bark and has anticancer and senescence modifying activities.1 It increases levels of P-glycoprotein (P-gp) and multidrug resistance protein 2 (MDR2) and enhances doxorubicin-induced cytotoxicity in doxorubicin-resistant K562/ADM cells when used at concentrations ranging from 5 to 20 µM. It also inhibits doxorubicin-induced senescence in isolated human dermal fibroblasts (HDFs), as well as replicative senescence in HDFs and human umbilical vein endothelial cells (HUVECs).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, Y., Liao, Z., Wei, X., et al. Epifriedelanol enhances adriamycin-induced cytotoxicity towards K562/ADM cells by down regulating of P-gp and MRP2. Xenobiotica 1-28 (2022).

    2. Yang, H.H., Son, J.-K., Jung, B., et al. Epifriedelanol from the root bark of Ulmus davidiana inhibits cellular senescence in human primary cells. Planta Med. 77(5), 441-449 (2011).