A diterpene alkaloid with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

3-Acetylaconitine

Item No. 36155

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
20-ethyl-1α,6α,16β-trimethoxy-4-(methoxymethyl)-aconitane-3α,8,13,14α,15α-pentol, 3,8-diacetate 14-benzoate
CAS Number
77181-26-1
Synonyms
  • Flaconitine
  • Monoacetylaconitine
Molecular Formula
C36H49NO12
Formula Weight
687.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetone: solubleChloroform: solubleDichloromethane: solubleDMSO: solubleEthyl Acetate: soluble
SMILES
CO[C@@H](C[C@H]1OC(C)=O)C([C@@](C[C@@]2([C@H]3OC)O)([H])[C@H](C2([H])OC(C4=CC=CC=C4)=O)[C@@]5([C@H]3O)OC(C)=O)([C@@]6([H])[C@@]17COC)C(N(C7)CC)C5[C@@H]6OC
InChi Code
InChI=1S/C36H49NO12/c1-8-37-16-33(17-43-4)22(47-18(2)38)14-23(44-5)35-21-15-34(42)30(48-32(41)20-12-10-9-11-13-20)24(21)36(49-19(3)39,29(40)31(34)46-7)25(28(35)37)26(45-6)27(33)35/h9-13,21-31,40,42H,8,14-17H2,1-7H3/t21-,22-,23+,24-,25?,26+,27-,28?,29+,30?,31+,33+,34-,35?,36-/m1/s1
InChi Key
RIPYIJVYDYCPKW-ASGNKLEUSA-N
Origin
Plant/Aconitum pendulum
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $32

    Add

    5 mg

    $109

    Add

    10 mg

    $172

    Add

    25 mg

    $349

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    3-Acetylaconitine is a diterpene alkaloid that has been found in Aconitum and has diverse biological activities.1,2 It is cytotoxic to P388 leukemia cells (IC50 = 18.6 µM).1 It inhibits brevetoxin binding to (IC50 = 1.3 µM), and increases free sodium and calcium concentrations in, rat brain synaptosomes. 3-Acetylaconitine (60-100 nM) induces arrhythmia in isolated guinea pig atria.2 In vivo, 3-acetylaconitine (100 µg/kg, i.v.) reduces paw licking, flicking, and shaking in a mouse model of formalin-induced inflammatory pain.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. He, Y.-Q., Yao, B.-H., and Ma, Z.-Y. Diterpenoid alkaloids from a Tibetan medicinal plant Aconitum richardsonianum var. pseudosessiliflorum and their cytotoxic activity. J. Pharm. Anal. 1(1), 57-59 (2011).

    2. Gutser, U.T., Friese, J., Heubach, J.F., et al. Mode of antinociceptive and toxic action of alkaloids of Aconitum spec. Naunyn Schmiedebergs Arch. Pharmacol. 375(1), 39-48 (1997).