A diterpene with antileishmanial and gastroprotective activities
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12-O-Methylcarnosic Acid

Item No. 36175

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4aR,10aS)-1,3,4,9,10,10a-hexahydro-5-hydroxy-6-methoxy-1,1-dimethyl-7-(1-methylethyl)-4a(2H)-phenanthrenecarboxylic acid
CAS Number
62201-71-2
Synonyms
  • Carnosic acid 12-methyl ether
  • 12-Methoxycarnosic Acid
Molecular Formula
C21H30O4
Formula Weight
346.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Soluble
SMILES
CC(C)C(C=C1C([C@]2(C(O)=O)[C@@](C(C)(CCC2)C)([H])CC1)=C3O)=C3OC
InChi Code
InChI=1S/C21H30O4/c1-12(2)14-11-13-7-8-15-20(3,4)9-6-10-21(15,19(23)24)16(13)17(22)18(14)25-5/h11-12,15,22H,6-10H2,1-5H3,(H,23,24)/t15-,21+/m0/s1
InChi Key
QQNSARJGBPMQDI-YCRPNKLZSA-N
Origin
Plant/Rosmarinus officinalis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    12-O-Methylcarnosic acid is a diterpene that has been found in S. repens and has antileishmanial and gastroprotective activities.1,2 It induces mortality in L. donovani amastigotes (IC50 = 0.75 µM).1 12-O-Methylcarnosic acid (10 mg/kg) reduces lesion area in a mouse model of hydrochloric acid and ethanol-induced gastric ulcers.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mokoka, T.A., Peter, X.K., Fouche, G., et al. Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens burch. ex benth. (lamiaceae). S. Afr. J. Bot. 90, 93-95 (2014).

    2. Theodulz, C., Pertino, M.W., Rodríguez, J.A., et al. Gastroprotective effect and cytotoxicity of carnosic acid derivatives. Planta Med. 77(9), 882-887 (2011).