A chloride channel inhibitor
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9-Anthracenecarboxylic Acid

Item No. 36180

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
723-62-6
Synonyms
  • 9-AC
  • Anthracene-9-carboxylic Acid
  • 9-Anthroic Acid
  • 9-Carboxyanthracene
  • NSC 151909
Molecular Formula
C15H10O2
Formula Weight
222.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): insol
λmax
253 nm
SMILES
O=C(C1=C2C=CC=CC2=CC3=C1C=CC=C3)O
InChi Code
InChI=1S/C15H10O2/c16-15(17)14-12-7-3-1-5-10(12)9-11-6-2-4-8-13(11)14/h1-9H,(H,16,17)
InChi Key
XGWFJBFNAQHLEF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $62

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    25 g

    $123

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    50 g

    $229

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    Product Description

    9-Anthracenecarboxylic acid is a chloride channel inhibitor.1 It inhibits spontaneous transient inward currents (IC50s = 90 and 300 µM at +50 and -50 mV, respectively) and caffeine-evoked calcium-activated chloride currents (IC50 = 650 µM) in isolated rabbit portal vein smooth muscle cells. 9-Anthracenecarboxylic acid (100 µM) prevents decreases in the peritubular cell membrane potential in isolated frog (R. esculenta) kidney perfused with low-chloride Ringer’s solution.2 It has also been used as a building block in the synthesis of luminescent lanthanide complexes.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hogg, R.C., Wang, Q., and Large, W.A. Effects of Cl channel blockers on Ca-activated chloride and potassium currents in smooth muscle cells from rabbit portal vein. Br. J. Pharmacol. 111(4), 1333-1341 (1994).

    2. Oberleithner, H., Ritter, M., Lang, F., et al. Anthracene-9-carboxylic acid inhibits renal chloride reabsorption. Pflugers Arch. 398(2), 172-174 (1983).

    3. Casanovas, B., Speed, S., Maury, O., et al. Homodinuclear lanthanide 9-anthracenecarboxylate complexes: Field induced SMM and NIR-luminescence. Polyhedron 169, 187-194 (2019).