A pan-ALDH1A inhibitor
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CM10

Item No. 36186

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2-propen-1-yl)-6-[[(1-propyl-1H-benzimidazol-2-yl)amino]methyl]-phenol
CAS Number
692269-09-3
Molecular Formula
C20H23N3O
Formula Weight
321.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
OC1=C(CNC2=NC3=CC=CC=C3N2CCC)C=CC=C1CC=C
InChi Code
InChI=1S/C20H23N3O/c1-3-8-15-9-7-10-16(19(15)24)14-21-20-22-17-11-5-6-12-18(17)23(20)13-4-2/h3,5-7,9-12,24H,1,4,8,13-14H2,2H3,(H,21,22)
InChi Key
ZFHWEWJDCFGRBO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $33

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    10 mg

    $62

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    25 mg

    $130

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    50 mg

    $209

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    Cayman Chemical
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    Product Description

    CM10 is a pan-aldehyde dehydrogenase 1 (ALDH1A) inhibitor (IC50s = 1,700, 740, and 640 nM for human ALDH1A1, ALDH1A2, and ALDH1A3, respectively).1 It is selective for ALDH1A isoforms over ALDH2, -3A1, -4A1, -5A1, -1B1, and -1L1 at 20 µM. CM10 induces necroptosis in ovarian cancer stem cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1.  .