A flavonoid aglycone with potassium channel inhibitory and anticancer activities
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4',7-Di-O-methylnaringenin

Item No. 36190

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2S,3-dihydro-5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CAS Number
29424-96-2
Synonyms
  • Naringenin 4',7-dimethyl ether
Molecular Formula
C17H16O5
Formula Weight
300.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
215, 227, 287 nm
SMILES
OC1=C2C(O[C@@H](CC2=O)C3=CC=C(OC)C=C3)=CC(OC)=C1
InChi Code
InChI=1S/C17H16O5/c1-20-11-5-3-10(4-6-11)15-9-14(19)17-13(18)7-12(21-2)8-16(17)22-15/h3-8,15,18H,9H2,1-2H3/t15-/m0/s1
InChi Key
CKEXCBVNKRHAMX-HNNXBMFYSA-N
Origin
Plant/Aglaia odorata
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    4',7-Di-O-methylnaringenin is a flavonoid aglycone that has been found in Vitex quinata and has potassium channel inhibitory and anticancer activities.1,2 It inhibits the voltage-gated potassium channel subtype Kv1.3 in a patch-clamp assay when used at a concentration of 30 µM.1 4’,7-Di-O-methylnaringenin is cytotoxic to human LNCaP prostate, Lu1 lung, and MCF-7 breast cancer cells (EC50s = 6.7, 4.7, and 1.1 µM, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Teisseyre, A., Duarte, N., Ferreira, M.-J.U., et al. Influence of the multidrug transporter inhibitors on the activity of Kv1.3 voltage-gated potassium channels. J. Physiol. Pharmacol. 60(1), 69-76 (2009).

    2. Deng, Y., Chin, Y.-W., Chai, H.-B., et al. Phytochemical and bioactivity studies on constituents of the leaves of Vitex quinata. Phytochem. Lett. 4(3), 213-217 (2011).