A phenol glucoside with diverse biological activities
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Androsin

Item No. 36191

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[4-(β-D-glucopyranosyloxy)-3-methoxyphenyl]-ethanone
CAS Number
531-28-2
Molecular Formula
C15H20O8
Formula Weight
328.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: soluble
λmax
224, 268, 302 nm
SMILES
COC(C=C(C=C1)C(C)=O)=C1O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO
InChi Code
InChI=1S/C15H20O8/c1-7(17)8-3-4-9(10(5-8)21-2)22-15-14(20)13(19)12(18)11(6-16)23-15/h3-5,11-16,18-20H,6H2,1-2H3/t11-,12-,13+,14-,15-/m1/s1
InChi Key
QUOZWMJFTQUXON-UXXRCYHCSA-N
Origin
Plant/Nerium indicum
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Androsin is a phenol glucoside that has been found in P. kurroa and has diverse biological activities.1,2,3 It is active against the bacteria S. aureus, S. epidermidis, P. aeruginosa, E. cloacae, K. pneumoniae, and E. coli (MICs = 0.6, 0.68, 0.97, 0.85, 1, and 1.08 mg/ml, respectively) and the fungi C. albicans, C. tropicalis, and C. glabrata (MICs = 1.85, 1.7, and 1.65 mg/ml, respectively).3 Androsin (10 mg/kg) inhibits bronchial obstruction in a guinea pig model of asthma induced by ovalbumin or platelet-activating factor (PAF).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stuppner, H., and Wagner, H. Minor iridoid and phenol glycosides of Picrorhiza kurrooa. Planta Med. 55(5), 467-469 (1988).

    2. Dorsch, W., Stuppner, H., Wagner, H., et al. Antiasthmatic effects of Picrorhiza kurroa: Androsin prevents allergen- and PAF-induced bronchial obstruction in guinea pigs. Int. Arch. Allergy Appl. Immunol. 95(2-3), 128-133 (1991).

    3. Zajdel, S.M., Graikou, K., Sotiroudis, G., et al. Two new iridoids from selected Penstemon species - antimicrobial activity. Nat. Prod. Res. 27(24), 2263-2271 (2013).