A nucleotide diphosphate
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2'-Deoxyadenosine-5'-O-diphosphate (sodium salt)

Item No. 36195

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2′-deoxy-adenosine 5′-(trihydrogen diphosphate), trisodium salt
CAS Number
402491-35-4
Synonyms
  • dADP
  • 2'-deoxy-ADP
Molecular Formula
C10H12N5O9P2 • 3Na
Formula Weight
477.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
260 nm
SMILES
NC1=NC=NC2=C1N=CN2[C@@]3([H])C[C@H](O)[C@@H](COP(OP([O-])([O-])=O)([O-])=O)O3.[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C10H15N5O9P2.3Na/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19;;;/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19);;;/q;3*+1/p-3/t5-,6+,7+;;;/m0.../s1
InChi Key
OFUJHRQLQPLGNA-PWDLANNDSA-K
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $62

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    10 mg

    $117

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    25 mg

    $274

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    50 mg

    $486

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    Product Description

    2'-Deoxyadenosine-5'-O-diphosphate (dADP) (sodium salt) is a purine nucleotide diphosphate.1 It inhibits the polymerization of ADP and CDP by E. coli or P. fluorescens polynucleotide phosphorylase when used at a concentration of 0.23 mM.2 dADP levels are increased in erythrocytes isolated from patients with adenosine deaminase (ADA) deficiency, an inborn error of metabolism characterized by severe combined immunodeficiency (SCID).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Berg, J.M., Tymoczko, J.L., and Stryer, L. Nucleotide biosynthesis. Biochemistry (2002).

    2. Lucas-Lenard, J.M., and Cohen, S.S. The inhibition of polynucleotide phosphorylase by certain substrate analogues. Biochim. Biophys. Acta 123(3), 471-477 (1966).

    3. Coleman, M.S., Donofrio, J., Hutton, J.J., et al. Identification and quantitation of adenine deoxynucleotides in erythrocytes of a patient with adenosine deaminase deficiency and severe combined immunodeficiency. The Journal of Biological Chemisty 253(5), 1619-1626 (1978).