A sphingolipid
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Globopentaosylceramide (porcine RBC)

Item No. 36242

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
O-β-D-galactopyranosyl(1→3)-O-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl-(1→3)-O-α-D-galactopyranosyl-(1→4)-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranose
CAS Number
171108-15-9
Synonyms
  • Gb5
  • Globoside Gb5
  • SSEA-3
  • Stage-specific Embryonic Antigen-3
Molecular Formula
C74H136N2O28
Formula Weight
1501.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
CC(N[C@H]([C@H]([C@H]([C@H](O1)CO)O)O[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2O)O)O)CO)[C@@H]1O[C@@H]3[C@H]([C@H](O[C@@H]([C@@H]3O)CO)O[C@@H]4[C@@H](O)[C@H](O[C@@H]5[C@@H](CO)O[C@@H](OC[C@H](NC([R])=O)[C@H](O)/C=C/CCCCCCCCCCCCC)[C@H](O)[C@H]5O)O[C@H](CO)[C@@H]4O)O)=O
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $569

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    Product Description

    Globopentaosylceramides are glycosphingolipids and cell surface markers.1,2,3,4 They are present during oogenesis and preimplantation embryonic development and on primitive endoderm, extraembryonic visceral endoderm, embryonic stem cells, and pluripotent multilineage-differentiating stress-enduring (Muse) cells.1,2,3 Globopentaosylceramides are also present on cancer stem cells.4 This product contains globopentaosylceramides with primarily C24:0, C22:0, and 2-hydroxy C24:0 fatty acyl chains. As this product is derived from a natural source, there may be variations in the sphingoid backbone.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Handa, K., and Hakomori, S.-I. Changes of glycoconjugate expression profiles during early development. Glycoconj. J. 34(6), 693-699 (2017).

    2. Muramatsu, T., and Muramatsu, H. Carbohydrate antigens expressed on stem cells and early embryonic cells. Glycoconj. J. 21(1-2), 41-45 (2004).

    3. Wakao, S., Kushida, Y., and Dezawa, M. Basic characteristics of muse cells. Adv. Exp. Med. Biol. 1103, 13-41 (2018).

    4. Cheung, S.K., Chuang, P.K., Huang, H.W., et al. Stage-specific embryonic antigen-3 (SSEA-3) and β3GalT5 are cancer specific and significant markers for breast cancer stem cells. Proc. Nat. Acad. Sci. USA 113(4), 960-965 (2016).