A metabolite of L-phenylalanine
Related Products
Parent Compound(s)
31498L-Phenylalanine
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N-Acetyl-L-phenylalanine

Item No. 36253

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
2018-61-3
Synonyms
  • Acetyl-L-phenylalanine
  • Acetylphenylalanine
  • NSC 45699
Molecular Formula
C11H13NO3
Formula Weight
207.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 12 mg/mlEthanol: Slightly solublePBS (pH 7.2): 0.25 mg/ml
SMILES
OC([C@@H](NC(C)=O)CC1=CC=CC=C1)=O
InChi Code
InChI=1S/C11H13NO3/c1-8(13)12-10(11(14)15)7-9-5-3-2-4-6-9/h2-6,10H,7H2,1H3,(H,12,13)(H,14,15)/t10-/m0/s1
InChi Key
CBQJSKKFNMDLON-JTQLQIEISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

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    Cayman Chemical
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    Product Description

    N-Acetyl-L-phenylalanine is a metabolite of L-phenylalanine (Item No. 31498).1 It is formed from L-phenylalanine by gut microbiota. Serum levels of N-acetyl-L-phenylalanine are increased in male COVID-19 patients compared with female COVID-19 patients and individuals without COVID-19, and hippocampal levels of N-acetyl-L-phenylalanine are increased in postmortem brain tissue isolated from patients with Alzheimer's disease.1,2 Urinary levels of N-acetyl-L-phenylalanine are negatively correlated with phthalate exposure in normal weight, but not overweight, children.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Escarcega, R.D., Honarpisheh, P., Colpo, G.D., et al. Sex differences in global metabolomic profiles of COVID-19 patients. Cell Death Dis. 13(5), 461 (2022).

    2. Liu, P., Yang, Q., Yu, N., et al. Phenylalanine metabolism is dysregulated in human hippocampus with Alzheimer’s disease related pathological changes. J. Alzheimers Dis. 83(2), 609-622 (2021).

    3. Xia, B., Zhu, Q., Zhao, Y., et al. Phthalate exposure and childhood overweight and obesity: Urinary metabolomic evidence. Environ. Int. 121(Pt 1), 159-168 (2018).