An intermediate of T4 biosynthesis
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3,5-Diiodo-L-tyrosine

Item No. 36266

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-2-amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid
CAS Number
300-39-0
Synonyms
  • 3,5-Diiodotyrosine
  • DIT
  • NSC 4143
Molecular Formula
C9H9I2NO3
Formula Weight
433.0
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleDMSO: 10 mg/mlEthanol: Slightly solublePBS (pH 7.2): 0.30 mg/ml
λmax
220 nm
SMILES
OC([C@@H](N)CC1=CC(I)=C(C(I)=C1)O)=O
InChi Code
InChI=1S/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1
InChi Key
NYPYHUZRZVSYKL-ZETCQYMHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 g

    $32

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    25 g

    $74

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    50 g

    $118

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    100 g

    $217

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    Product Description

    3,5-Diiodo-L-tyrosine is an intermediate in the biosynthesis of the thyroid hormone thyroxine (T4).1 It inhibits tyrosine hydroxylase (IC50 = 20 µM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tietge, J.E., S.J., D., Haselman, J.T., et al. Inhibition of the thyroid hormone pathway in Xenopus laevis by 2-mercaptobenzothiazole. Aquat. Toxicol. 126, 128-136 (2013).

    2. Udenfriend, S., Zaltzman-Nirenberg, P., and Nagatsu, T. Inhibitors of purified beef adrenal tyrosine hydroxylase. Biochem. Pharmacol. 14(4), 837-845 (1965).