A synthetic dipeptide non-caloric sweetener
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Alitame

Item No. 36267

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-aspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)-D-alaninamide
CAS Number
80863-62-3
Synonyms
  • CP 54,802
Molecular Formula
C14H25N3O4S
Formula Weight
331.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C([C@@H](C)NC([C@@H](N)CC(O)=O)=O)NC(C1(C)C)C(C)(S1)C
InChi Code
InChI=1S/C14H25N3O4S/c1-7(16-11(21)8(15)6-9(18)19)10(20)17-12-13(2,3)22-14(12,4)5/h7-8,12H,6,15H2,1-5H3,(H,16,21)(H,17,20)(H,18,19)/t7-,8+/m1/s1
InChi Key
IVBOUFAWPCPFTQ-SFYZADRCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $53

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    50 mg

    $101

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    100 mg

    $191

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    Product Description

    Alitame is a synthetic dipeptide non-caloric sweetener.1,2 It binds to the Venus fly trap domain of the class 1 sweet taste receptor subunit TAS1R2 (Kd = 0.15 µM for the recombinant human receptor).1 It substitutes for sucrose in the two-bottle preference test in non-human primates.2 Formulations containing alitame have been used as sweetening agents and flavor enhancers in foods and beverages.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Laffitte, A., Belloir, C., Neiers, F., et al. Functional characterization of the Venus flytrap domain of the human TAS1R2 sweet taste receptor. Int. J. Mol. Sci. 23(16), 9216 (2022).

    2. Glaser, D., Tinti, J.M., and Nofre, C. Evolution of the sweetness receptor in primates. I. Why does alitame taste sweet in all prosimians and simians, and aspartame only in Old World simians? Clinical Trial 20(5), 573-584 (1995).