A metabolite of dofetilide
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Parent Compound(s)
15045Dofetilide
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Dofetilide N-oxide

Item No. 36294

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]oxidoamino]ethyl]phenyl]-methanesulfonamide
CAS Number
144449-71-8
Synonyms
  • CS 0019807
  • UK 116856
Molecular Formula
C19H27N3O6S2
Formula Weight
457.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: insolDMSO: 1 mg/mlEthanol: insolPBS (pH 7.2): insol
λmax
231 nm
SMILES
[O-][N+](CCOC1=CC=C(NS(=O)(C)=O)C=C1)(CCC2=CC=C(NS(=O)(C)=O)C=C2)C
InChi Code
InChI=1S/C19H27N3O6S2/c1-22(23,13-12-16-4-6-17(7-5-16)20-29(2,24)25)14-15-28-19-10-8-18(9-11-19)21-30(3,26)27/h4-11,20-21H,12-15H2,1-3H3
InChi Key
AYRPGSAYHYJPGA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $32

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    5 mg

    $118

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    10 mg

    $186

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    25 mg

    $271

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    Product Description

    Dofetilide N-oxide is a metabolite of the antiarrhythmic agent dofetilide (Item No. 15045).1 It prolongs intracellular action potential duration in isolated guinea pig papillary muscle, as a measure of antiarrhythmic activity, less potently than dofetilide.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Walker, D.K., Alabaster, C.T., Congrave, G.S., et al. Significance of metabolism in the disposition and action of the antidysrhythmic drug, dofetilide. In vitro studies and correlation with in vivo data. Drug Metab. Dispos. 24(4), 447-455 (1996).