An internal standard for the quantification of 2’-deoxyuridine
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Unlabeled Version(s)
278032'-Deoxyuridine
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2′-Deoxyuridine-d2

Item No. 36323

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2′-deoxy-uridine-5,6-d2
CAS Number
40632-23-3
Synonyms
  • Uracil deoxyribose-d2
Molecular Formula
C9H10D2N2O5
Formula Weight
230.2
Purity
≥99% deuterated forms (d1-d2)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 10 mg/mlEthanol: Slightly solublePBS (pH 7.2): 5 mg/ml
SMILES
OC[C@H]1O[C@](N2C(NC(C([2H])=C2[2H])=O)=O)([H])C[C@@H]1O
InChi Code
InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1/i1D,2D
InChi Key
MXHRCPNRJAMMIM-AQAQJVFASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    2’-Deoxyuridine-d2 is intended for use as an internal standard for the quantification of 2’-deoxyuridine (Item No. 27803) by GC- or LC-MS. 2’-Deoxyuridine is a pyrimidine nucleoside composed of the pyrimidine base uracil (Item No. 26088) attached to the sugar deoxyribose.1 It has been used as a precursor in the synthesis of antiviral deoxyuridine derivatives, including idoxuridine (Item No. 20222).2,3 Formulations containing 2’-deoxyuridine have been used in the deoxyuridine suppression test to identify vitamin B12 and/or folate deficiency and in the diagnosis of megaloblastic anemias.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Martí, R., López, L.C., and Hirano, M. Assessment of thymidine phosphorylase function: Measurement of plasma thymidine (and deoxyuridine) and thymidine phosphorylase activity. Methods Mol. Biol. 837, 121-133 (2012).

    2. Prusoff, W.H. Synthesis and biological activities of iododeoxyuridine, an analog of thymidine. Biochim. Biophys. Acta 32(1), 295-296 (1959).

    3. Bergstrom, D.E., and Ogawa, M.K. C-5 substituted pyrimidine nucleosides. 2. Synthesis via olefin coupling to organopalladium intermediates derived from uridine to 2'-deoxyuridine. J. Am. Chem. Soc. 100(26), 8106-8112 (1978).