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11-nor-9(R)-carboxy-Hexahydrocannabinol

Item No. 36355

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • 11-carboxy-9β-Hexahydrocannabinol
  • 11-carboxy-HHC
  • 11-carboxy-9β-HHC
  • 11-carboxy-9(R)-HHC
  • ​9(R)-HHC-COOH
  • 11-nor-9β-carboxy-Hexahydrocannabinol
  • 11-nor-9β-carboxy-HHC
Technical Information
Formal Name
[6aR-(6aα,9α,10aβ)]-6a,7,8,9,10,10a-hexahydro-1-hydroxy-6,6-dimethyl-3-pentyl-6H-dibenzo[b,d]pyran-9-carboxylic acid
CAS Number
64663-38-3
Molecular Formula
C21H30O4
Formula Weight
346.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 0.3 mg/ml
SMILES
CC1(C)[C@@]2([H])[C@](C[C@H](C(O)=O)CC2)([H])C3=C(C=C(CCCCC)C=C3O)O1
InChi Code
InChI=1S/C21H30O4/c1-4-5-6-7-13-10-17(22)19-15-12-14(20(23)24)8-9-16(15)21(2,3)25-18(19)11-13/h10-11,14-16,22H,4-9,12H2,1-3H3,(H,23,24)/t14-,15-,16-/m1/s1
InChi Key
VRZWHTKBFZGYJJ-BZUAXINKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    11-nor-9(R)-carboxy-Hexahydrocannabinol (Item No. 36355) is an analytical reference standard that is structurally similar to known phytocannabinoids.1 11-nor-9(R)-carboxy-Hexahydrocannabinol is a metabolite of exo-THC (Item No. 36898) and 9-hexahydrocannabinol.1,2 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Harvey, D.J. The mass spectra of the trimethylsilyl derivatives of cis- and trans- hexahydrocannabinol and their hydroxy and acid analogues. Biomed. Mass Spectrom. 8(8), 366-372 (1981).

    2. Di Trana, A., Di Giorgi, A., Sprega, G., et al. Disposition of hexahydrocannabinol epimers and their metabolites in biological matrices following a single administration of smoked hexahydrocannabinol: A preliminary study. Pharmaceuticals (Basel) 17(2), 249 (2024).

    Product Citations

    Schirmer, W., Walton, S.E., Weinmann, W., et al. Rapid LC-QTOF-MS screening method for semi-synthetic cannabinoids in whole blood. J. Anal. Toxicol. bkaf095 (2025).

    Lindbom, K., Norman, C., Baginski, S., et al. Human metabolism of the semi-synthetic cannabinoids hexahydrocannabinol, hexahydrocannabiphorol and their acetates using hepatocytes and urine samples. Drug Test Anal. (2024).

    Jørgensen, C.F., Rasmussen, B.S., Linnet, K., et al. Evidence of 11-hydroxy-hexahydrocannabinol and 11-nor-9-carboxy-hexahydrocannabinol as Novel Human Metabolites of Δ9-tetrahydrocannabinol. Metabolites 13(12), 1169 (2023).