A biologically active form of vitamin E
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(+)-γ-Tocopherol

Item No. 36362

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R)-3,4-dihydro-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
CAS Number
54-28-4
Synonyms
  • all-(R)-γ-Tocopherol
  • D-γ-Tocopherol
Molecular Formula
C28H48O2
Formula Weight
416.7
Purity
≥90%
Formulation (Request formulation change)
A neat liquid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 15 mg/mlEthanol: 15 mg/ml
SMILES
CC1=C2C(CC[C@@](C)(O2)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=CC(O)=C1C
InChi Code
InChI=1S/C28H48O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-19-26(29)23(5)24(6)27(25)30-28/h19-22,29H,8-18H2,1-7H3/t21-,22-,28+/m1/s1
InChi Key
QUEDXNHFTDJVIY-XJGOYTCSSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

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    50 mg

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    100 mg

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    Product Description

    (+)-γ-Tocopherol is a biologically active form of vitamin E.1,2,3 It inhibits the growth of DU145, LNCaP, and Caco-2 cancer cells when used at a concentration of 25 µM.1 In vivo, (+)-γ-tocopherol (100 mg/kg) reduces airway eosinophil infiltration and levels of IL-6, IL-5, IL-13, and chemokine (C-C motif) ligand 2 (CCL2) in a rat model of ovalbumin-induced allergic inflammation and a rat model of ovalbumin- and ozone-induced asthma.2 It also reduces lipid peroxidation in vitamin E-depleted, iron-loaded rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gysin, R., Azzi, A., and Visarius, T. γ-Tocopherol inhibits human cancer cell cycle progression and cell proliferation by down-regulation of cyclins. The FASEB Journal 16(14), 1952-1954 (2002).

    2. Wagner, J.G., Jiang, Q., Harkema, J.R., et al. Ozone enhancement of lower airway allergic inflammation is prevented by γ-tocopherol. Free Radic. Biol. Med. 43(8), 1176-1188 (2007).

    3. Dillard, C.J., Gavino, V.C., and Tappel, A.L. Relative antioxidant effectiveness of α-tocopherol and γ-tocopherol in iron-loaded rats. J. Nutr. 113(11), 2266-2273 (1983).