A glycine conjugate of phenylacetate
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Phenylacetylglycine

Item No. 36368

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-phenylacetyl)-glycine
CAS Number
500-98-1
Synonyms
  • NSC 408424
  • NSC 92778
  • PAG
  • PAGly
  • Phenaceturic Acid
  • N-Phenylacetylglycine
Molecular Formula
C10H11NO3
Formula Weight
193.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
SMILES
O=C(CNC(CC1=CC=CC=C1)=O)O
InChi Code
InChI=1S/C10H11NO3/c12-9(11-7-10(13)14)6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,11,12)(H,13,14)
InChi Key
UTYVDVLMYQPLQB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    25 mg

    $33

    Add

    50 mg

    $55

    Add

    100 mg

    $98

    Add

    250 mg

    $163

    Add
    Product Description

    Phenylacetylglycine is a glycine conjugate of phenylacetate.1,2,3,4 It is formed via the conversion of phenylalanine by gut microbiota to phenylacetic acid followed by glycine conjugation in the liver.1,5 Phenylacetylglycine (100 µM) decreases hypoxia-induced apoptosis in neonatal mouse cardiomyocytes.2 Levels of phenylacetylglycine in urine and plasma are increased in a rat model of phospholipidosis induced by the antiarrhythmic agent amiodarone (Item No. 15213).4 Phenylacetylglycine reduces myocardial infarct size in a mouse model of ischemia-reperfusion injury.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nemet, I., Saha, P.P., Gupta, N., et al. A cardiovascular disease-linked gut microbial metabolite acts via adrenergic receptors. Cell 180(5), 862-877.e822 (2020).

    2. Xu, X., Lu, W.-J., Shi, J.-Y., et al. The gut microbial metabolite phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion through activating β2AR. Arch. Biochem. Biophys. 697, 108720 (2021).

    3. Jones, A.R. Some observations on the urinary excretion of glycine conjugates by laboratory animals. Xenobiotica 12(6), 387-395 (1982).

    4. Kamiguchi, H., Murabayashi, M., Mori, I., et al. Biomarker discovery for drug-induced phospholipidosis: Phenylacetylglycine to hippuric acid ratio in urine and plasma as potential markers. Biomarkers 22(2), 178-188 (2016).

    5. Zhu, Y., Dwidar, M., Nemet, I., et al. Two distinct gut microbial pathways contribute to meta-organismal production of phenylacetylglutamine with links to cardiovascular disease. Cell Host Microbe 31(1), 18-32.e19 (31(1)).