An inhibitor of MAO-A
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5-hydroxy Isatin

Item No. 36383

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-hydroxy-1H-indole-2,3-dione
CAS Number
116569-09-6
Molecular Formula
C8H5NO3
Formula Weight
163.1
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 5 mg/mlEthanol: insolPBS (pH 7.2): insol
λmax
214, 255 nm
SMILES
O=C1NC2=CC=C(C=C2C1=O)O
InChi Code
InChI=1S/C8H5NO3/c10-4-1-2-6-5(3-4)7(11)8(12)9-6/h1-3,10H,(H,9,11,12)
InChi Key
SZEUAVRUUFUMIU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $136

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    50 mg

    $608

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    100 mg

    $1,078

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    Product Description

    5-hydroxy Isatin is an inhibitor of monoamine oxidase A (MAO-A; IC50 = 8.4 µM).1 It is selective for MAO-A over MAO-B (IC50 = >100 µM). 5-hydroxy Isatin (50 µM) also inhibits atrial natriuretic peptide-induced activation of particulate guanylyl cyclase in rat brain and heart membranes.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Medvedev, A.E., Goodwin, B., Chow, A., et al. Inhibitory potency of some isatin analogues on human monoamine oxidase A and B. Biochem. Pharmacol. 44(3), 590-592 (1992).

    2. Medvedev, A.E., Goodwin, B.L., Sandler, M., et al. Efficacy of isatin analogues as antagonists of rat brain and heart atrial natriuretic peptide receptors coupled to particulate guanylyl cyclase. Biochem. Pharmacol. 57(8), 913-915 (1999).