An Mcl-1 inhibitor
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MIK665

Item No. 36404

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
αR-[[(5S)-5-[3-chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-phenyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[2-(2-methoxyphenyl)-4-pyrimidinyl]methoxy]-benzenepropanoic acid
CAS Number
1799631-75-6
Synonyms
  • S64315
Molecular Formula
C47H44ClFN6O6S
Formula Weight
875.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C(C(CC1=C(OCC2=NC(C3=C(OC)C=CC=C3)=NC=C2)C=CC=C1)OC4=C5C(C6=C(C)C(Cl)=C(OCCN7CCN(CC7)C)C=C6)=C(C8=CC=C(C=C8)F)SC5=NC=N4)O
InChi Code
InChI=1S/C47H44ClFN6O6S/c1-29-34(16-17-38(42(29)48)59-25-24-55-22-20-54(2)21-23-55)40-41-45(51-28-52-46(41)62-43(40)30-12-14-32(49)15-13-30)61-39(47(56)57)26-31-8-4-6-10-36(31)60-27-33-18-19-50-44(53-33)35-9-5-7-11-37(35)58-3/h4-19,28,39H,20-27H2,1-3H3,(H,56,57)
InChi Key
PKYIMGFMRFVOMB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $185

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    5 mg

    $599

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    10 mg

    $1,105

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    Product Description

    MIK665 is an inhibitor of myeloid cell leukemia-1 (Mcl-1; Ki = 1.2 nM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Du, J., Liu, L., Liu, B., et al. Structure-based virtual screening, biological evaluation and biophysical study of novel Mcl-1 inhibitors. Future Med. Chem. 12(14), 1293-1304 (2020).