A steroidal glycoalkaloid metabolite with anticancer and teratogenic activities
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Product Categories

Product Type

Biochemicals
Lipids
Sterol Lipids
Natural Products
Alkaloids

Research Area

Cancer

Solanidine

Item No. 36433

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β)-solanid-5-en-3-ol
CAS Number
80-78-4
Synonyms
  • (–)-Solanidine
  • 22R,25S-Solanidine
  • NSC 76025
Molecular Formula
C27H43NO
Formula Weight
397.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: solubleMethanol: soluble
SMILES
C[C@@]12[C@]3([H])[C@@](C[C@@]1([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H](CC5)O)=CC4)C)([H])CC2)([H])N6[C@@](CC[C@@H](C6)C)([H])[C@H]3C
InChi Code
InChI=1S/C27H43NO/c1-16-5-8-23-17(2)25-24(28(23)15-16)14-22-20-7-6-18-13-19(29)9-11-26(18,3)21(20)10-12-27(22,25)4/h6,16-17,19-25,29H,5,7-15H2,1-4H3/t16-,17+,19-,20+,21-,22-,23+,24-,25-,26-,27-/m0/s1
InChi Key
JVKYZPBMZPJNAJ-OQFNDJACSA-N
Origin
Plant/Solanum tuberosum L.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Solanidine is a steroidal glycoalkaloid metabolite that has been found in potato (S. tuberosum) and has anticancer and teratogenic activities.1,2,3 It inhibits the growth of HT-29 colon and HepG2 liver cancer cells by 80.9 and 82.2%, respectively, when used at a concentration of 100 μg/ml.2 Solanidine (176 mg/kg) is teratogenic to hamster embryos when administered to pregnant dams on day eight of gestation.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nikolic, N.C., and Stankovic, M.Z. Solanidine hydrolytic extraction and separation from the potato (Solanum tuberosum L.) vines by using solid-liquid-liquid systems. J. Agric. Food Chem. 51(7), 1845-1849 (2003).

    2. Lee, K.-R., Kozukue, N., Han, J.-S., et al. Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells. J. Agric. Food Chem. 52(10), 2832-2839 (2004).

    3. Gaffield, W., and Keeler, R.F. Implication of C-5, C-6 unsaturation as a key structural factor in steroidal alkaloid-induced mammalian teratogenesis. Experientia 49(10), 922-924 (1993).