A catabolite of uracil
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Product Categories

Product Type

Biochemicals
Nucleotides/Nucleosides

Research Area

5,6-Dihydrouracil

Item No. 36438

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
dihydro-2,4(1H,3H)-pyrimidinedione
CAS Number
504-07-4
Synonyms
  • NSC 11867
Molecular Formula
C4H6N2O2
Formula Weight
114.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: insolDMSO: 1 mg/mlEthanol: insolPBS (pH 7.2): 1 mg/ml
SMILES
O=C1NC(CCN1)=O
InChi Code
InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8)
InChi Key
OIVLITBTBDPEFK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    5 g

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    10 g

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    Product Description

    5,6-Dihydrouracil is a catabolite of uracil (Item No. 26088).1 It is formed from uracil by dihydropyrimidine dehydrogenase. The plasma ratio of 5,6-dihydrouracil to uracil has been used as a phenotypic marker of dihydropyrimidine dehydrogenase activity.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Büchel, B., Rhyn, P., Schürch, S., et al. LC-MS/MS method for simultaneous analysis of uracil, 5,6-dihydrouracil, 5-fluorouracil and 5-fluoro-5,6-dihydrouracil in human plasma for therapeutic drug monitoring and toxicity prediction in cancer patients. Biomed. Chromatogr. 27(1), 7-16 (2013).

    2. Chavani, O., Jensen, B.P., Strother, R.M., et al. Development, validation and application of a novel liquid chromatography tandem mass spectrometry assay measuring uracil, 5,6-dihydrouracil, 5-fluorouracil, 5,6-dihydro-5-fluorouracil, α-fluoro-β-ureidopropionic acid and α-fluoro-β-alanine in human plasma. J. Pharm. Biomed. Anal. 142, 125-135 (2017).