An active metabolite of L-DOPA
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Parent Compound(s)
13248L-DOPA
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3-Methoxytyrosine

Item No. 36443

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methoxy-tyrosine
CAS Number
7636-26-2
Synonyms
  • DL-3-O-Methyldopa
  • NSC 122476
  • 3-methoxy-DL-Tyrosine
Molecular Formula
C10H13NO4
Formula Weight
211.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleChloroform: Slightly solubleDMF: Slightly solubleDMSO: Slightly solublePBS (pH 7.2): Slightly solubleWater: Slightly soluble
SMILES
O=C(C(CC1=CC=C(C(OC)=C1)O)N)O
InChi Code
InChI=1S/C10H13NO4/c1-15-9-5-6(2-3-8(9)12)4-7(11)10(13)14/h2-3,5,7,12H,4,11H2,1H3,(H,13,14)
InChi Key
PFDUUKDQEHURQC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $74

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    50 mg

    $132

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    100 mg

    $235

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    250 mg

    $366

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    Product Description

    3-Methoxytyrosine is an active metabolite of L-DOPA (Item No. 13248).1 It is formed from L-DOPA via O-methylation by catechol-O-methyltransferase (COMT). 3-Methoxytyrosine (10 and 100 µM) inhibits L-DOPA-induced neuroprotection in primary rat mesencephalic dopaminergic neurons.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Miller, J.W., Shukitt-Hale, B., Villalobos-Molina, R., et al. Effect of ʟ-Dopa and the catechol-O-methyltransferase inhibitor Ro 41-0960 on sulfur amino acid metabolites in rats. Clin. Neuropharmacol. 20(1), 55-66 (1997).

    2. Asanuma, M., and Miyazaki, I. 3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of ʟ-DOPA. BMC Neurosci. 17(1), 52 (2016).