A positive allosteric modulator of α2- and α3 subunit-containing GABAA receptors
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AZD 7325

Item No. 36449

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propyl-3-cinnolinecarboxamide
CAS Number
942437-37-8
Synonyms
  • BAER-101
Molecular Formula
C19H19FN4O2
Formula Weight
354.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
220, 345 nm
SMILES
O=C(C1=C(N)C2=CC=CC(C3=C(OC)C=CC=C3F)=C2N=N1)NCCC
InChi Code
InChI=1S/C19H19FN4O2/c1-3-10-22-19(25)18-16(21)12-7-4-6-11(17(12)23-24-18)15-13(20)8-5-9-14(15)26-2/h4-9H,3,10H2,1-2H3,(H2,21,23)(H,22,25)
InChi Key
KYDURMHFWXCKMW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $148

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    10 mg

    $234

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    Product Description

    AZD 7325 is a positive allosteric modulator of α2- and α3 subunit-containing GABAA receptors and a neutral antagonist for α1 subunit-containing GABAA receptors.1 It binds to GABAA receptors in membranes from Sf9 cells expressing α2β3γ2 subunit-containing receptors (Ki = 0.309 nM). AZD 7325 (1 mg/kg) increases marble-burying behavior, indicating anxiety-like activity, and decreases audiogenic seizure severity in the Fmr1-/- mouse model of fragile X syndrome.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alhambra, C., Becker, C., Blake, T.A., et al. Development and SAR of functionally selective allosteric modulators of GABAA receptors. Bioorg. Med. Chem. 19(9), 2927-2938 (2011).

    2. Schaefer, T.L., Ashworth, A.A., Tiwari, D., et al. GABAA alpha 2,3 modulation improves select phenotypes in a mouse model of fragile X syndrome. Front. Psychiatry 12, 678090 (2021).