A DOT1L inhibitor
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DOT1L-IN-4

Item No. 36456

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1-[(S)-(3-chloro-2-pyridinyl)(2,2-difluoro-1,3-benzodioxol-4-yl)methyl]-N2-[4-methoxy-6-(1-piperazinyl)-1,3,5-triazin-2-yl]-4-(methylsulfonyl)-1,2-benzenediamine
CAS Number
2565705-02-2
Synonyms
  • DOT1-like Inhibitor 4
Molecular Formula
C28H27ClF2N8O5S
Formula Weight
661.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
237, 276 nm
SMILES
COC1=NC(N2CCNCC2)=NC(NC(C=C(C=C3)S(C)(=O)=O)=C3N[C@H](C4=C(C=CC=N4)Cl)C5=C6C(OC(F)(O6)F)=CC=C5)=N1
InChi Code
InChI=1S/C28H27ClF2N8O5S/c1-42-27-37-25(36-26(38-27)39-13-11-32-12-14-39)35-20-15-16(45(2,40)41)8-9-19(20)34-22(23-18(29)6-4-10-33-23)17-5-3-7-21-24(17)44-28(30,31)43-21/h3-10,15,22,32,34H,11-14H2,1-2H3,(H,35,36,37,38)/t22-/m0/s1
InChi Key
QJIMSJUUARCROQ-QFIPXVFZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $33

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    5 mg

    $146

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    10 mg

    $258

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    25 mg

    $482

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    Product Description

    DOT1L-IN-4 is an inhibitor of the non-SET domain-containing methyltransferase DOT1L (IC50 = 0.11 nM).1 It is selective for DOT1L over a panel of 11 additional histone methyltransferases at 5 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stauffer, F., Weiss, A., Scheufler, C., et al. New potent DOT1L inhibitors for in vivo evaluation in mouse. ACS Med. Chem. Lett. 10(12), 1655-1660 (2019).