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Undecanedioic acid is a medium-chain dicarboxylic acid that has been found in S. officinalis.1,2 It is active against T. rubrum, T. mentagrophytes, and M. canis when used at a concentration of 1 mM.2 Undecanedioic acid has been used in the synthesis of proteolysis-targeting chimeras (PROTACs) with anticancer activity in mutant EGFR-expressing cancer cells.3 It has been found in urban and industrial aerosols of fine particulate matter less than 2.5 µm (PM2.5).4
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1. Comparative analysis of phytochemical composition of ethanolic extract of Jordanian Silvia officinalis. Pak. J. Biol. Sci. 23(8), 989-994 (2022).
2. Dicarboxylic acids affect the growth of dermatophytes in vitro. Acta Derm. Venereol. 74(5), 347-350 (1994).
3. Design and synthesis of proteolysis targeting chimeras (PROTACs) as an EGFR degrader based on CO-
4. Fine particles sampled at an urban background site and an industrialized coastal site in Northern France -