A STING activator
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KAS 08

Item No. 36474

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4S)-1-[[2,3-dihydro-1-(4-nitrobenzoyl)-1H-indol-5-yl]sulfonyl]-4-phenyl-2-imidazolidinone
CAS Number
203861-20-5
Molecular Formula
C24H20N4O6S
Formula Weight
492.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 12 mg/mlEthanol: 12 mg/mlPBS (pH 7.2): 0.25 mg/ml
λmax
272 nm
SMILES
O=C(C1=CC=C([N+]([O-])=O)C=C1)N2CCC3=CC(S(=O)(N4C(N[C@](C5=CC=CC=C5)([H])C4)=O)=O)=CC=C32
InChi Code
InChI=1S/C24H20N4O6S/c29-23(17-6-8-19(9-7-17)28(31)32)26-13-12-18-14-20(10-11-22(18)26)35(33,34)27-15-21(25-24(27)30)16-4-2-1-3-5-16/h1-11,14,21H,12-13,15H2,(H,25,30)/t21-/m1/s1
InChi Key
PHTUTOMJUWFHHH-OAQYLSRUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $119

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    5 mg

    $530

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    10 mg

    $998

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    Cayman Chemical
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    Product Description

    KAS 08 is an activator of stimulator of interferon genes (STING).1 It activates STING with an EC50 value of 0.33 µM in a reporter assay using THP-1 human monocytes. KAS 08 increases the levels of IFN-β and IP-10 in the presence, but not absence, of cGAMP. It reduces the viability of CT26 mouse colorectal cancer cells when used at concentrations ranging from 0.31 to 20 µM. KAS 08 (15 mg/kg), when administered in combination with exogenous 2’3’-cGAMP (Item No. 19887), reduces tumor growth in a CT26 mouse syngeneic model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jung, H.R., Jo, S., Jeon, M.J., et al. Development of small-molecule STING activators for cancer immunotherapy. Biomedicines 10(1), 33 (2022).