An amide with antiplatelet and DNA-cleaving activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

1-Cinnamoylpyrrolidine

Item No. 36483

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-3-phenyl-1-(1-pyrrolidinyl)-2-propen-1-one
CAS Number
52438-21-8
Molecular Formula
C13H15NO
Formula Weight
201.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetone: solubleChloroform: solubleDichloromethane: solubleDMSO: solubleEthyl Acetate: soluble
SMILES
O=C(N1CCCC1)/C=C/C2=CC=CC=C2
InChi Code
InChI=1S/C13H15NO/c15-13(14-10-4-5-11-14)9-8-12-6-2-1-3-7-12/h1-3,6-9H,4-5,10-11H2/b9-8+
InChi Key
JSIGICUAXLIURX-CMDGGOBGSA-N
Origin
Plant/Alkaloids
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $44

    Add

    1 mg

    $84

    Add

    5 mg

    $283

    Add
    Product Description

    1-Cinnamoylpyrrolidine is an amide that has been found in P. taiwanense and has antiplatelet and DNA-cleaving activities.1,2 It inhibits arachidonic acid- or collagen-induced aggregation of isolated washed rabbit platelets (IC50s = 30.5 and 37.3 µM, respectively).1 1-Cinnamoylpyrrolidine (250 µM) cleaves DNA in a cell-free DNA strand scission assay in the presence, but not absence, of copper ions.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, I.-S., Chen, Y.-C., and Liao, C.-H. Amides with anti-platelet aggregation activity from Piper taiwanense. Fitoterapia 78(6), 414-419 (2007).

    2. Ma, J., Jones, S.H., and Hecht, S.M. Phenolic acid amides: A new type of DNA strand scission agent from Piper caninum. Bioorg. Med. Chem. 12(14), 3885-3889 (2004).