A coumarin with anti-inflammatory activity
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Product Categories

Product Type

Biochemicals
Natural Products
Coumarins

Research Area

Immunology & Inflammation

Dimethylfraxetin

Item No. 36485

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6,7,8-trimethoxy-2H-1-benzopyran-2-one
CAS Number
6035-49-0
Synonyms
  • Fraxetin dimethyl ether
  • 6,7,8-Trimethoxycoumarin
Molecular Formula
C12H12O5
Formula Weight
236.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
227 nm
SMILES
O=C1OC2=C(C=C1)C=C(OC)C(OC)=C2OC
InChi Code
InChI=1S/C12H12O5/c1-14-8-6-7-4-5-9(13)17-10(7)12(16-3)11(8)15-2/h4-6H,1-3H3
InChi Key
RAYQKHLZHPFYEJ-UHFFFAOYSA-N
Origin
Plant/Fraxinus chinensis Roxb. bark
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $38

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    5 mg

    $141

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    10 mg

    $244

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    25 mg

    $468

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    Product Description

    Dimethylfraxetin is a coumarin that has been found in T. lucida and has anti-inflammatory activity.1 It reduces auricular edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice when administered at a dose of 1 mg/ear.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nayeli, M.-B., Maribel, H.-R., Enrique, J.-F., et al. Anti-inflammatory activity of coumarins isolated from Tagetes lucida Cav. Nat. Prod. Res. 34(22), 3244-3248 (2020).