A flavonoid glycoside with hepatotoxic activity
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

2''-O-Rhamnosylicariside II

Item No. 36487

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[6-deoxy-2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-mannopyranosyl]oxy]-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
CAS Number
135293-13-9
Synonyms
  • 2”-O-Rhys II
Molecular Formula
C33H40O14
Formula Weight
660.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
C/C(C)=C\CC1=C2C(C(C(O[C@H]3[C@@H]([C@@H]([C@H]([C@@H](O3)C)O)O)O[C@H]4[C@@H]([C@@H]([C@H]([C@@H](O4)C)O)O)O)=C(C5=CC=C(C=C5)OC)O2)=O)=C(C=C1O)O
InChi Code
InChI=1S/C33H40O14/c1-13(2)6-11-18-19(34)12-20(35)21-24(38)30(28(45-29(18)21)16-7-9-17(42-5)10-8-16)46-33-31(26(40)23(37)15(4)44-33)47-32-27(41)25(39)22(36)14(3)43-32/h6-10,12,14-15,22-23,25-27,31-37,39-41H,11H2,1-5H3/t14-,15-,22-,23-,25+,26+,27+,31+,32-,33-/m0/s1
InChi Key
TVBJKPLTBPGHDJ-ZJTKNEERSA-N
Origin
Plant/Epimedium brevicornu
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $98

    Add

    5 mg

    $440

    Add

    10 mg

    $781

    Add
    Product Description

    2”-O-Rhamnosylicariside II (2”-O-Rhys II) is a flavonoid glycoside that has been found in Epimedium and has hepatotoxic activity.1,2 It increases aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and malondialdehyde (MDA) levels, as well as decreases glutathione (GSH) levels in Hl 7702 cells when used at a concentration of 66 µg/ml. 2’-O-Rhys II (100 µM) induces 100% mortality in zebrafish larvae.2 It also induces hepatocellular vacuolization and degeneration in adult zebrafish when used at a concentration of 25 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, L., Wang, T., Zhao, B.-S., et al. Effect of 2″-O-rhamnosyl icariside II, baohuoside I and baohuoside II in Herba epimedii on cytotoxicity indices in HL-7702 and HepG2 cells. Molecules 24(7), 1236 (2019).

    2. Zhong, R., Chen, Y., Ling, J., et al. The toxicity and metabolism properties of Herba epimedii flavonoids on laval and adult zebrafish. Evid. Based Complement. Alternat. Med. 3745051 (2019).