A dopamine D4 receptor agonist
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Product Type

Small Molecule Modulators
Receptor Pharmacology
Agonists

Research Area

Cancer

CP 226,269

Item No. 36493

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-fluoro-2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-indole
CAS Number
220941-93-5
Molecular Formula
C18H19FN4
Formula Weight
310.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 31 mg/ml
SMILES
FC1=CC=C2NC(CN3CCN(CC3)C4=CC=CC=N4)=CC2=C1
InChi Code
InChI=1S/C18H19FN4/c19-15-4-5-17-14(11-15)12-16(21-17)13-22-7-9-23(10-8-22)18-3-1-2-6-20-18/h1-6,11-12,21H,7-10,13H2
InChi Key
PQOIDBZLMJMYCD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $141

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    10 mg

    $248

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    25 mg

    $542

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    Cayman Chemical
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    Product Description

    CP 226,269 is a dopamine D4 receptor agonist.1 It induces calcium flux in HEK293 cells co-expressing human dopamine D4, but not D2L or D3, receptors and Gαqo5 (EC50s = 32, >10,000, and 985 nM, respectively). CP 226,269 induces phospholipid methylation in SK-N-MC neuroblastoma cells, which endogenously express dopamine D1 and D4 receptors (EC50 = 2.9 nM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Moreland, R.B., Nakane, M., Donnelly-Roberts, D., et al. Comparative pharmacology of human dopamine D2-like receptor stable cell lines coupled to calcium flux through Gɑqo5. Biochem. Pharmacol. 68(4), 761-772 (2004).

    2. Sharma, A., Kramer, M.L., Wick, P.F., et al. D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophrenia. Mol. Psychiatry 4(3), 235-246 (1999).