An inhibitor of Wnt/β-catenin signaling
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

MSAB

Item No. 36497

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[(4-methylphenyl)sulfonyl]amino]-benzoic acid, methyl ester
CAS Number
173436-66-3
Molecular Formula
C15H15NO4S
Formula Weight
305.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 25 mg/mlEthanol: 10 mg/ml
λmax
214 nm
SMILES
O=C(C1=CC(NS(=O)(C2=CC=C(C)C=C2)=O)=CC=C1)OC
InChi Code
InChI=1S/C15H15NO4S/c1-11-6-8-14(9-7-11)21(18,19)16-13-5-3-4-12(10-13)15(17)20-2/h3-10,16H,1-2H3
InChi Key
CVKBYFCJQSPBOI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $33

    Add

    25 mg

    $66

    Add

    50 mg

    $91

    Add

    100 mg

    $163

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    MSAB is an inhibitor of Wnt/β-catenin signaling.1 It binds to β-catenin and promotes its proteasomal degradation in HCT116 cells. MSAB (2-10 µM) selectively inhibits the proliferation of Wnt-dependent cancer cells over non-cancerous cells and Wnt-independent cancer cells. It reduces Wnt3a-induced increases in β-catenin levels in a reporter assay using HEK293T cells. MSAB decreases the expression of the Wnt target genes AXIN2, MYC, CCND1, and BMP4 in a concentration-dependent manner in HCT116 cells. It reduces tumor growth and increases intratumoral apoptosis in Wnt-dependent HCT116, HT115, and H23 mouse xenograft models when administered at doses of 10 and 20 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hwang, S.-Y., Deng, X., Byun, S., et al. Direct targeting of β-catenin by a small molecule stimulates proteasomal degradation and suppresses oncogenic Wnt/β-catenin signaling. Cell Rep. 16(1), 28-36 (2016).