An intestinal permeation enhancer
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Salcaprozate (sodium salt)

Item No. 36505

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-[(2-hydroxybenzoyl)amino]-octanoic acid, monosodium salt
CAS Number
203787-91-1
Synonyms
  • SNAC
Molecular Formula
C15H20NO4 • Na
Formula Weight
301.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlEthanol: Slightly solublePBS (pH 7.2): 1 mg/ml
SMILES
O=C(CCCCCCCNC(C1=C(O)C=CC=C1)=O)[O-].[Na+]
InChi Code
InChI=1S/C15H21NO4.Na/c17-13-9-6-5-8-12(13)15(20)16-11-7-3-1-2-4-10-14(18)19;/h5-6,8-9,17H,1-4,7,10-11H2,(H,16,20)(H,18,19);/q;+1/p-1
InChi Key
UOENJXXSKABLJL-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    250 mg

    $29

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    500 mg

    $54

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    1 g

    $96

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    5 g

    $337

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    Product Description

    Salcaprozate is an intestinal permeation enhancer.1 It increases jejunal accumulation of the bioactive antioxidant peptide PW5 in vitro in a non-everted rat gut sac model. In vivo, salcaprozate increases plasma concentrations of orally administered human parathyroid hormone (1-34) in pigs.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, Y., Amakye, W.K., Xiao, G., et al. Intestinal absorptivity-increasing effects of sodium N-[8-(2-hydroxybenzoyl)amino]-caprylate on food-derived bioactive peptide. Food Chem. 401, 134059 (2023).

    2. Burshtein, G., Itin, C., Tang, J.C.Y., et al. The combined effect of permeation enhancement and proteolysis inhibition on the systemic exposure of orally administrated peptides: Salcaprozate sodium, soybean trypsin inhibitor, and teriparatide study in pigs. Int. J. Pharm. X. 3, 100097 (2021).