A phenylethanoid glycoside with diverse biological activities
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2'-Acetylacteoside

Item No. 36511

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside, 2-acetate 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]
CAS Number
94492-24-7
Molecular Formula
C31H38O16
Formula Weight
666.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
λmax
220, 335 nm
SMILES
CC(O[C@@H]([C@@H](O[C@@H]([C@H]1OC(/C=C/C2=CC(O)=C(C=C2)O)=O)CO)OCCC3=CC(O)=C(C=C3)O)[C@H]1O[C@H]4[C@@H]([C@@H]([C@H]([C@@H](O4)C)O)O)O)=O
InChi Code
InChI=1S/C31H38O16/c1-14-24(39)25(40)26(41)30(43-14)47-28-27(46-23(38)8-5-16-3-6-18(34)20(36)11-16)22(13-32)45-31(29(28)44-15(2)33)42-10-9-17-4-7-19(35)21(37)12-17/h3-8,11-12,14,22,24-32,34-37,39-41H,9-10,13H2,1-2H3/b8-5+/t14-,22+,24-,25+,26+,27+,28-,29+,30-,31+/m0/s1
InChi Key
ALERZNQPBWWLMW-OMRKUVHCSA-N
Origin
Plant/Cistanche deserticola
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $55

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    1 mg

    $105

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    5 mg

    $301

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    10 mg

    $544

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    Product Description

    2'-Acetylacteoside is a phenylethanoid glycoside that has been found in C. deserticola and has diverse biological activities.1,2,3,4,5 It selectively inhibits aldose reductase over maltase and sucrase (IC50s = 0.071, >300, and 277 µM, respectively, for the rat enzymes).1 2'-Acetylacteoside scavenges superoxide radicals in a cell-free assay and inhibits hemolysis induced by AAPH (Item No. 82235) in isolated rat red blood cells in a concentration-dependent manner.2 It decreases glutamate-induced cytotoxicity in primary rat cortical neurons when used at concentrations of 0.1, 1, and 10 µM and protects primary mouse hepatocytes against D-galactosamine-induced cytotoxicity (IC50 = 4.8 µg/ml).3,4 2'-Acetylacteoside (10-40 mg/kg) prevents decreases in bone strength in ovariectomized mice.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Morikawa, T., Ninomiya, K., Imamura, M., et al. Acylated phenylethanoid glycosides, echinacoside and acteoside from Cistanche tubulosa, improve glucose tolerance in mice. J. Nat. Med. 68(3), 561-566 (2014).

    2. He, Z.-D., Lau, K.-M., Xu, H.-X., et al. Antioxidant activity of phenylethanoid glycosides from Brandisia hancei. J. Ethnopharmacol. 71(3), 483-486 (2000).

    3. Koo, K.A., Sung, S.H., Park, J.H., et al. In vitro neuroprotective activities of phenylethanoid glycosides from Callicarpa dichotoma. Planta Med. 71(8), 778-780 (2005).

    4. Morikawa, T., Pan, Y., Ninomiya, K., et al. Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa. Bioorg. Med. Chem. 18(5), 1882-1890 (2010).

    5. Li, Y., Li, N., Zhao, X., et al. Beneficial effect of 2'-acetylacteoside on ovariectomized mice via modulating the function of bone resorption. Biomed. Pharmacother. 131, 110747 (2020).