An alkaloid with anticancer and antiviral activities
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Cephalotaxine

Item No. 36521

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
24316-19-6
Synonyms
  • (–)-Cephalotaxine
  • NSC 128487
  • NSC 245454
  • ZINC19795976
Molecular Formula
C18H21NO4
Formula Weight
315.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 12 mg/mlEthanol: 5 mg/ml
SMILES
O[C@H]1[C@]2([H])[C@]3(C=C1OC)N(CCC3)CCC4=CC(OCO5)=C5C=C42
InChi Code
InChI=1S/C18H21NO4/c1-21-15-9-18-4-2-5-19(18)6-3-11-7-13-14(23-10-22-13)8-12(11)16(18)17(15)20/h7-9,16-17,20H,2-6,10H2,1H3/t16-,17-,18+/m1/s1
InChi Key
YMNCVRSYJBNGLD-KURKYZTESA-N
Origin
Plant/Taxus wallichiana
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    50 mg

    $91

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    100 mg

    $161

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    250 mg

    $291

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    Cayman Chemical
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    Product Description

    Cephalotaxine is an alkaloid that has been found in Cephalotaxus and has anticancer and antiviral activities.1,2,3 It is cytotoxic to HL-60, NB4, MOLT-4, K562, Jurkat, and Raji cells (IC50s = 4.91, 16.88, 7.09, 22.59, 5.54, and 18.08 µM, respectively).1 Cephalotaxine (5-20 µM) induces mitochondrial apoptosis, as well as impairs lysosomal acidification and autophagic flux in HL-60 cells. It reduces infectivity and hepatitis B virus (HBV) surface antigen (HBsAg) secretion in HBV-infected HepG2 2.2.15 cells when used at concentrations ranging from 10 to 100 µM.2 Cephalotaxine (20, 40, and 80 µM) also reduces viral infectivity in Zika virus-infected Vero cells.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, T., Guo, Q., Zheng, S., et al. Cephalotaxine inhibits the survival of Leukemia cells by activating mitochondrial apoptosis pathway and inhibiting autophagy flow. Molecules 26(10), 2996 (2021).

    2. Romero, M.R., Serrano, M.A., Efferth, T., et al. Effect of cantharidin, cephalotaxine and homoharringtonine on "in vitro" models of hepatitis B virus (HBV) and bovine viral diarrhoea virus (BVDV) replication. Planta Med. 73(6), 552-558 (2007).

    3. Lai, Z.-Z., Ho, Y.-J., and Lu, J.-W. Cephalotaxine inhibits Zika infection by impeding viral replication and stability. Biochem. Biophys. Res. Commun. 22(4), 1052-1058 (2020).