A valepotriate with diverse biological activities
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Valtrate

Item No. 36522

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
butanoic acid, 3-methyl-1′-[(1S,2′R,6S,7aS)-4-[(acetyloxy)methyl]-6,7a-dihydrospiro[cyclopenta[c]pyran-7(1H),2′-oxirane]-1,6-diyl]ester
CAS Number
18296-44-1
Synonyms
  • Halazuchrome B
Molecular Formula
C22H30O8
Formula Weight
422.5
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in chloroform
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleDMSO: solubleMethanol: slightly soluble
λmax
256 nm
SMILES
CC(C)CC(O[C@@H]1[C@]2(CO2)[C@]3([H])C(C(COC(C)=O)=CO[C@H]3OC(CC(C)C)=O)=C1)=O
InChi Code
InChI=1S/C22H30O8/c1-12(2)6-18(24)29-17-8-16-15(9-26-14(5)23)10-27-21(20(16)22(17)11-28-22)30-19(25)7-13(3)4/h8,10,12-13,17,20-21H,6-7,9,11H2,1-5H3/t17-,20+,21-,22+/m0/s1
InChi Key
BDIAUFOIMFAIPU-KVJIRVJXSA-N
Origin
Plant/Valeriana officinalis L.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

    $512

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    Product Description

    Valtrate is a valepotriate that has been found in Valeriana and has diverse biological activities.1,2,3 It inhibits nuclear export of influenza virus ribonucleoprotein complex (vRNP) in HeLa cells when used at a concentration of 3.6 µM and inhibits influenza virus infection in MDCK cells (IC50 = 0.19 µM).1 Valtrate is cytotoxic to GLC-4 lung and COLO 320 colorectal cancer cells (IC50s = 1.4 and 3 µM, respectively).2 It increases the number of entries into, and percentage of time spent in, the open arms of the elevated plus maze, indicating anxiolytic-like activity, and decreases serum corticosterone levels in rats when administered at a dose of 10 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Watanabe, K., Takatsuki, H., Sonoda, M., et al. Anti-influenza viral effects of novel nuclear export inhibitors from Valerianae Radix and Alpinia galanga. Drug Discov. Ther. 5(1), 26-31 (2016).

    2. Bos, R., Hendriks, H., Scheffer, J.J., et al. Cytotoxic potential of valerian constituents and valerian tinctures. Phytomedicine 5(3), 219-225 (1998).

    3. Shi, S.-N., Shi, J.-L., Liu, Y., et al. The anxiolytic effects of valtrate in rats involves changes of corticosterone levels. Evid. Based Complement. Alternat. Med. 325948 (2014).