Tapinarof

Tapinarof is a stilbene that has been found in P. luminescens and has diverse biological activities.^1,2 It is active against the fungi C. tropicales, C. neoformans, and A. fumigatus (MICs = 25, 12, and 12 µg/ml, respectively) and the plant pathogenic fungi A. flavus and B. cinerea (MICs = 25 and 12 µg/ml, respectively).¹ It induces nuclear translocation of the aryl hydrocarbon receptor (AhR; EC₅₀ = 0.16 nM) and expression of the AhR target gene CYP1A1 in HaCaT keratinocytes when used at a concentration of 1 µM.² Tapinarof (10 µM) reduces activated immune cell-induced mRNA expression of the gene encoding IL-17a in isolated human keratinocytes.^2,3 Formulations containing tapinarof have been used in the topical treatment of adult plaque psoriasis.

WARNING This product is not for human or veterinary use.

1. Li, J., Chen, G., Wu, H., et al. Identification of two pigments and a hydroxystilbene antibiotic from Photorhabdus luminescens. Appl. Environ. Microbiol. 61(12), 4329-4333 (1995).

2. Smith, S.H., Jayawickreme, C., Rickard, D.J., et al. Tapinarof is a natural AhR agonist that resolves skin inflammation in mice and humans. J. Invest. Dermatol. 137(10), 2110-2119 (2017).

3. Smith, S.H., Peredo, C.E., Takedo, Y., et al. Development of a topical treatment for psoriasis targeting RORγ: From bench to skin. PLoS One 11(2), e0147979 (2016).