A gut microbiota-derived metabolite of tyrosine and a uremic toxin
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Phenyl Sulfate

Item No. 36546

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
sulfuric acid, monophenyl ester
CAS Number
937-34-8
Molecular Formula
C6H6O4S
Formula Weight
174.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 17.4 mg/mlWater: 37.75 mg/ml
SMILES
O=S(O)(OC1=CC=CC=C1)=O
InChi Code
InChI=1S/C6H6O4S/c7-11(8,9)10-6-4-2-1-3-5-6/h1-5H,(H,7,8,9)
InChi Key
CTYRPMDGLDAWRQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $74

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    1 mg

    $140

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    5 mg

    $548

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    Product Description

    Phenyl sulfate is a gut microbiota-derived metabolite of tyrosine and a uremic toxin.1 It reduces survival of, as well as decreases glutathione (GSH) levels and induces mitochondrial dysfunction in, differentiated human urinary podocyte-like epithelial cells (HUPECs) when used at a concentration of 30 µM.2 Phenyl sulfate (50 mg/kg) induces podocyte damage and albuminuria in a db/db mouse model of diabetes. Increased plasma levels of phenyl sulfate correlate with the progression of albuminuria in patients with diabetic kidney disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mishima, E., Fukuda, S., Mukawa, C., et al. Evaluation of the impact of gut microbiota on uremic solute accumulation by a CE-TOFMS-based metabolomics approach. Kidney Int. 92(3), 634-645 (2017).

    2. Kikuchi, K., Saigusa, D., Kanemitsu, Y., et al. Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease. Nat. Commun. 10(1), 1835 (2019).