A diterpenoid alkaloid with antiarrhythmic activity
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12-Epinapelline

Item No. 36550

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R,6S,6aS,6bR,8R,9R,11R,11aR,12R,12aS,14R)-1-ethyldodecahydro-3-methyl-10-methylene-12,3,6a-ethanylylidene-9,11a-methanoazuleno[2,1-b]azocine-6,8,11-triol
CAS Number
110064-71-6
Synonyms
  • 12-epi Napelline
Molecular Formula
C22H33NO3
Formula Weight
359.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: 10 mg/mL
SMILES
O[C@@H]1[C@@]23[C@@]4([H])[C@]5(C[C@H](C([C@H]5O)=C)[C@@H](C4)O)[C@@H]6[C@@]2([H])N(C[C@@]([C@H]3C6)(CC1)C)CC
InChi Code
InChI=1S/C22H33NO3/c1-4-23-10-20(3)6-5-17(25)22-15(20)7-13(18(22)23)21-9-12(11(2)19(21)26)14(24)8-16(21)22/h12-19,24-26H,2,4-10H2,1,3H3/t12-,13+,14-,15-,16-,17+,18-,19-,20+,21+,22-/m1/s1
InChi Key
AZAZKLKDEOMJBJ-PQNIRSBSSA-N
Origin
Plant/Aconitum carmichaeli
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $174

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    25 mg

    $310

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    Product Description

    12-Epinapelline is a diterpenoid alkaloid that has been found in Aconitum and has antiarrhythmic activity.1 It has antiarrhythmic activity in a rat model of aconitine-induced arrhythmia and antifibrillatory activity in a mouse model of aconitine-induced cardiac fibrillation (ED50s = 8 and 20 mg/kg, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dzhakhangirov, F.N., Sultankhodzhaev, M.N., Tashkhodzhaev, B., et al. Diterpenoid alkaloids as a new class of antiarrhythmic agents. Structure-activity relationship. Chem. Nat. Compd. 33(2), 190-202 (1997).