An inhibitor of RNA polymerase I-mediated transcription
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Quarfloxin

Item No. 36552

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-fluoro-N-[2-[(2S)-1-methyl-2-pyrrolidinyl]ethyl]-3-oxo-6-[3-(2-pyrazinyl)-1-pyrrolidinyl]-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide
CAS Number
865311-47-3
Synonyms
  • CX-3543
  • Itarnafloxin
  • Quarfloxacin
Molecular Formula
C35H33FN6O3
Formula Weight
604.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
218, 319 nm
SMILES
O=C1C2=C3N(C=C1C(NCC[C@@H]4CCCN4C)=O)C5=CC6=CC=CC=C6C=C5OC3=C(N7CC(C8=NC=CN=C8)CC7)C(F)=C2
InChi Code
InChI=1S/C35H33FN6O3/c1-40-13-4-7-24(40)8-10-39-35(44)26-20-42-29-15-21-5-2-3-6-22(21)16-30(29)45-34-31(42)25(33(26)43)17-27(36)32(34)41-14-9-23(19-41)28-18-37-11-12-38-28/h2-3,5-6,11-12,15-18,20,23-24H,4,7-10,13-14,19H2,1H3,(H,39,44)/t23?,24-/m0/s1
InChi Key
WOQIDNWTQOYDLF-CGAIIQECSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $68

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    5 mg

    $300

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    10 mg

    $531

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    25 mg

    $994

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    Cayman Chemical
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    Product Description

    Quarfloxin is an inhibitor of RNA polymerase I-mediated transcription.1 It binds to G-quadruplex DNA and inhibits the interaction between ribosomal DNA G-quadruplexes and nucleolin, a nucleolar protein required for RNA polymerase I-mediated transcription. Quarfloxin (10 µM) induces nucleolin mislocalization from the nucleoli to the nucleoplasm in A549 cells. It induces apoptosis in A549 and HL-60 cells when used at a concentration of 5 µM. Quarfloxin (5 mg/kg) reduces tumor growth in MDA-MB-231 breast and MiaPaCa-2 pancreatic cancer mouse xenograft models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Drygin, D., Siddiqui-Jain, A., O'Brien, S., et al. Anticancer activity of CX-3543: A direct inhibitor of rRNA biogenesis. Cancer Res. 69(19), 7653-7661 (2009).