A Notch1 signaling modulator
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3,5-Bis(4-nitrophenoxy)benzoic Acid

Item No. 36553

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
173550-33-9
Synonyms
  • Compound W
Molecular Formula
C19H12N2O8
Formula Weight
396.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100mMEthanol: 5mM
λmax
299 nm
SMILES
O=C(C1=CC(OC2=CC=C([N+]([O-])=O)C=C2)=CC(OC3=CC=C([N+]([O-])=O)C=C3)=C1)O
InChi Code
InChI=1S/C19H12N2O8/c22-19(23)12-9-17(28-15-5-1-13(2-6-15)20(24)25)11-18(10-12)29-16-7-3-14(4-8-16)21(26)27/h1-11H,(H,22,23)
InChi Key
JOSXKPZXMVHRKU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $49

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    100 mg

    $87

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    500 mg

    $363

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    Product Description

    3,5-Bis(4-nitrophenoxy)benzoic acid is a Notch1 signaling modulator.1,2 It decreases the production of C-terminally elongated Notch1 amyloid-β-like peptide (Nβ25) from the full-length receptor, a marker of Notch1 intracellular domain release and transcription modification, in HEK293 cells.1 3,5-Bis(4-nitrophenoxy)benzoic acid (50 µM) also decreases activation of the Notch1 target hes family bHLH transcription factor 1 (HES1) in a luciferase reporter assay using HCT116 cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Okochi, M., Fukumori, A., Jiang, J., et al. Secretion of the Notch-1 Aβ-like peptide during Notch signaling. The Journal of Biological Chemisty 281(12), 7890-7898 (2006).

    2. Sail, V., and Hadden, M.K. Identification of small molecule Hes1 modulators as potential anticancer chemotherapeutics. Chem. Biol. Drug Des. 81(3), 334-342 (2013).