An inhibitor of HDAC6
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NN-390

Item No. 36564

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-hydroxy-4-[[(1-methylethyl)[(2,3,4,5-tetrafluorophenyl)sulfonyl]amino]methyl]-benzamide
CAS Number
2490284-25-6
Molecular Formula
C17H16F4N2O4S
Formula Weight
420.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
236 nm
SMILES
O=C(C1=CC=C(CN(S(=O)(C2=CC(F)=C(C(F)=C2F)F)=O)C(C)C)C=C1)NO
InChi Code
InChI=1S/C17H16F4N2O4S/c1-9(2)23(8-10-3-5-11(6-4-10)17(24)22-25)28(26,27)13-7-12(18)14(19)16(21)15(13)20/h3-7,9,25H,8H2,1-2H3,(H,22,24)
InChi Key
SJWJGLIJTRUXIZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $62

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    1 mg

    $109

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    5 mg

    $456

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    Product Description

    NN-390 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 9.8 nM).1 It is selective for HDAC6 over HDAC3, HDAC8, and HDAC11 (IC50s = >1,000 nM for all). NN-390 is cytotoxic to MV4-11 leukemia, MM.1S multiple myeloma, and HD-MB03 medulloblastoma cells (IC50s = 1.19, 1.38, and 0.13 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nawar, N., Bukhari, S., Adile, A.A., et al. Discovery of HDAC6-selective inhibitor NN-390 with in vitro efficacy in group 3 medulloblastoma. J. Med. Chem. 65(4), 3193-3217 (2022).