An anticancer nucleoside
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Kinetin Riboside

Item No. 36570

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-furanylmethyl)-adenosine
CAS Number
4338-47-0
Synonyms
  • N6-Furfuryladenosine
  • NSC 120958
Molecular Formula
C15H17N5O5
Formula Weight
347.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/ml
λmax
267 nm
SMILES
O[C@H]1[C@](O[C@@H]([C@H]1O)CO)([H])N2C3=NC=NC(NCC4=CC=CO4)=C3N=C2
InChi Code
InChI=1S/C15H17N5O5/c21-5-9-11(22)12(23)15(25-9)20-7-19-10-13(17-6-18-14(10)20)16-4-8-2-1-3-24-8/h1-3,6-7,9,11-12,15,21-23H,4-5H2,(H,16,17,18)/t9-,11-,12-,15-/m1/s1
InChi Key
CAGLGYNQQSIUGX-SDBHATRESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $91

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    5 g

    $223

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    Product Description

    Kinetin riboside is a purine derivative and nucleoside with anticancer activity.1 It induces the production of reactive oxygen species (ROS), cellular ATP depletion, and apoptosis in HepG2 cells. Kinetin riboside (10 µM) reduces cyclin D1 and cyclin D2 levels, as well as induces cell cycle arrest at the G1 phase and apoptosis in patient-derived multiple myeloma cells.2 In vivo, kinetin riboside (85 mg/kg) reduces tumor growth in OCI-My5 and RPMI-8226 myeloma mouse xenograft models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Orlicka-Płocka, M., Gurda-Wozna, D., Fedoruk-Wyszomirska, A., et al. Circumventing the Crabtree effect: Forcing oxidative phosphorylation (OXPHOS) via galactose medium increases sensitivity of HepG2 cells to the purine derivative kinetin riboside. Apoptosis 25(11-12), 835-852 (2020).

    2. Tiedemann, R.E., Mao, X., Shi, C.-X., et al. Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity. J. Clin. Invest. 118(5), 1750-1764 (2008).