A positive allosteric modulator of AMPA receptors
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UoS 12258

Item No. 36571

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide
CAS Number
875927-64-3
Molecular Formula
C17H19FN2O2S
Formula Weight
334.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 2 mg/mlEthanol: 1 mg/ml
λmax
250 nm
SMILES
CC(C)S(N[C@@H]1CC2=CC(C3=CN=C(F)C=C3)=CC=C2C1)(=O)=O
InChi Code
InChI=1S/C17H19FN2O2S/c1-11(2)23(21,22)20-16-8-13-4-3-12(7-15(13)9-16)14-5-6-17(18)19-10-14/h3-7,10-11,16,20H,8-9H2,1-2H3/t16-/m0/s1
InChi Key
QXQSUBKWSHMXDP-INIZCTEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $124

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    10 mg

    $234

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    50 mg

    $979

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    Product Description

    UoS 12258 is a positive allosteric modulator of AMPA receptors.1 It potentiates glutamate-induced currents in HEK293 cells expressing human ionotropic glutamate receptor 2 (GluR2) homomeric AMPA receptors (EC50 = 2.51 µM), as well as HEK293 cells expressing GluR1, GluR3, or GluR4 homomeric AMPA receptors. UoS 12258 (0.3 and 1 mg/kg) increases novel object exploration in a novel object recognition test in rats. It also reduces escape latencies in the Morris water maze in aged rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ward, S.E., Beswick, P., Calcinaghi, N., et al. Pharmacological characterization of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2, 3-dihydro-1H-inden-2-yl]-2-propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator. Br. J. Pharmacol. 174(5), 370-385 (2017).