An inhibitor of Y593-phosphorylated DDX5
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Supinoxin

Item No. 36573

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxy-2-quinoxalinyl)-1-piperazinecarboxamide
CAS Number
888478-45-3
Synonyms
  • RX-5902
Molecular Formula
C22H24FN5O4
Formula Weight
441.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 10 mg/ml
λmax
216, 252 nm
SMILES
O=C(N1CCN(CC1)C2=CC(OC)=CC(OC)=C2)NC3=NC4=C(N=C3OC)C=CC(F)=C4
InChi Code
InChI=1S/C22H24FN5O4/c1-30-16-11-15(12-17(13-16)31-2)27-6-8-28(9-7-27)22(29)26-20-21(32-3)25-18-5-4-14(23)10-19(18)24-20/h4-5,10-13H,6-9H2,1-3H3,(H,24,26,29)
InChi Key
KAKPGJJRYRYSTP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $70

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    5 mg

    $274

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    10 mg

    $480

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    25 mg

    $942

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    Cayman Chemical
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    Product Description

    Supinoxin is an inhibitor of Y593-phosphorylated DEAD-box helicase 5 (DDX5).1 It binds to Y593-phosphorylated DDX5 (Kd = ~19 nM), but does not interact with unphosphorylated DDX5, and selectively inhibits β-catenin-dependent ATPase activity over RNA-dependent ATPase activity at 0.2 µM. Supinoxin induces apoptosis in MDA-MB-231 cells (IC50 = 12 nM) and inhibits cell growth in SK-MEL-28 cells (IC50 = 20 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kost, G.C., Yang, M.Y., Li, L., et al. A novel anti-cancer agent, 1-(3,5-dimethoxyphenyl)-4-[(6-fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl] piperazine (RX-5902), interferes with β-catenin function through Y593 phospho-p68 RNA helicase. J. Cell. Biochem. 116(8), 1595-1601 (2015).