An inhibitor of Mre11 endonuclease activity
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PFM01

Item No. 36574

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5Z-[(4-hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone
CAS Number
1558598-41-6
Molecular Formula
C14H15NO2S2
Formula Weight
293.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 29.3 mg/ml
SMILES
OC(C=C1)=CC=C1/C=C2SC(N(CC(C)C)C\2=O)=S
InChi Code
InChI=1S/C14H15NO2S2/c1-9(2)8-15-13(17)12(19-14(15)18)7-10-3-5-11(16)6-4-10/h3-7,9,16H,8H2,1-2H3/b12-7-
InChi Key
GPURHDUTZUYAFI-GHXNOFRVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $53

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    10 mg

    $95

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    25 mg

    $222

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    Cayman Chemical
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    Product Description

    PFM01 is an inhibitor of the endonuclease activity of the double-strand break repair protein Mre11.1 It decreases the number of chromosomal breaks in 1BR3 fibroblasts induced by knockdown of BRCA2. PFM01 (50 µM) reduces homologous recombination-mediated DNA repair in DR-GFP U2OS cells and enhances DNA repair mediated by non-homologous end-joining (NHEJ) in H1299 dA3 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shibata, A., Moiani, D., Arvai, A.S., et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol. Cell 53(1), 7-18 (2014).