An inhibitor of TNF-α
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C-87

Item No. 36578

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-(4-chloro-3-nitrophenyl)hydrazone]3-phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione
CAS Number
332420-90-3
Molecular Formula
C24H15ClN6O3S
Formula Weight
502.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10mg/ml (warmed and sonicated)
λmax
247, 403 nm
SMILES
ClC(C([N+]([O-])=O)=C1)=CC=C1N/N=C(C(C2=CC=CC=C2)=N3)/C(N3C4=NC(C5=CC=CC=C5)=CS4)=O
InChi Code
InChI=1S/C24H15ClN6O3S/c25-18-12-11-17(13-20(18)31(33)34)27-28-22-21(16-9-5-2-6-10-16)29-30(23(22)32)24-26-19(14-35-24)15-7-3-1-4-8-15/h1-14,27H/b28-22+
InChi Key
VELQTEBILFDDQX-XAYXJRQQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $112

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    10 mg

    $212

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    25 mg

    $501

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    Product Description

    C-87 is an inhibitor of TNF-α.1 It binds to TNF-α and reduces the levels of phosphorylated JNK, prevents TNF-α-induced IκBα degradation, and inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 µM) in L-929 cells. It reduces liver inflammation and injury, as well as increases survival, in a mouse model of acute hepatitis induced by LPS and galactosamine (GalN) when administered at a dose of 12.5 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ma, L., Gong, H., Zhu, H., et al. A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model. The Journal of Biological Chemisty 289(18), 12457-12466 (2014).