An inhibitor of TNF-α
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

C-87

Item No. 36578

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-(4-chloro-3-nitrophenyl)hydrazone]3-phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione
CAS Number
332420-90-3
Molecular Formula
C24H15ClN6O3S
Formula Weight
502.9
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10mg/ml (warmed and sonicated)
λmax
247, 403 nm
SMILES
ClC(C([N+]([O-])=O)=C1)=CC=C1N/N=C(C(C2=CC=CC=C2)=N3)/C(N3C4=NC(C5=CC=CC=C5)=CS4)=O
InChi Code
InChI=1S/C24H15ClN6O3S/c25-18-12-11-17(13-20(18)31(33)34)27-28-22-21(16-9-5-2-6-10-16)29-30(23(22)32)24-26-19(14-35-24)15-7-3-1-4-8-15/h1-14,27H/b28-22+
InChi Key
VELQTEBILFDDQX-XAYXJRQQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $112

    Add

    10 mg

    $212

    Add

    25 mg

    $501

    Add
    Product Description

    C-87 is an inhibitor of TNF-α.1 It binds to TNF-α and reduces the levels of phosphorylated JNK, prevents TNF-α-induced IκBα degradation, and inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 µM) in L-929 cells. It reduces liver inflammation and injury, as well as increases survival, in a mouse model of acute hepatitis induced by LPS and galactosamine (GalN) when administered at a dose of 12.5 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ma, L., Gong, H., Zhu, H., et al. A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model. The Journal of Biological Chemisty 289(18), 12457-12466 (2014).