A PROTAC that drives BTK degradation
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

MT-802

Item No. 36581

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2-[2-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1, 3-dioxo-1H-isoindol-5-yl]-acetamide
CAS Number
2231744-29-7
Molecular Formula
C41H41N9O8
Formula Weight
787.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly solubleDMSO: SolubleMethanol: Slightly soluble
SMILES
O=C1C2=CC=C(NC(COCCOCCN3CCC(CC3)N4N=C(C5=C4N=CN=C5N)C6=CC=C(OC7=CC=CC=C7)C=C6)=O)C=C2C(N1C8C(NC(CC8)=O)=O)=O
InChi Code
InChI=1S/C41H41N9O8/c42-37-35-36(25-6-9-29(10-7-25)58-28-4-2-1-3-5-28)47-50(38(35)44-24-43-37)27-14-16-48(17-15-27)18-19-56-20-21-57-23-34(52)45-26-8-11-30-31(22-26)41(55)49(40(30)54)32-12-13-33(51)46-39(32)53/h1-11,22,24,27,32H,12-21,23H2,(H,45,52)(H2,42,43,44)(H,46,51,53)
InChi Key
AJTLGUJXIKEZCQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $47

    Add

    25 mg

    $208

    Add

    50 mg

    $370

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    MT-802 is a proteolysis-targeting chimera (PROTAC) composed of the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib (Item No. 16274) linked to the cereblon inhibitor pomalidomide (Item No. 19877).1 It induces degradation of BTK in NAMALWA cells when used at concentrations ranging from 10 to 250 nM. MT-802 (1 µM) induces BTK degradation in primary X-linked agammaglobulinemia (XLA) cells expressing wild-type BTK or the ibrutinib-resistant mutant BTKC481S. It also induces BTK degradation in patient-derived chronic lymphocytic leukemia (CLL) cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Buhimschi, A.D., Armstrong, H.A., Toure, M., et al. Targeting the C481S ibrutinib-resistance mutation in Bruton’s tyrosine kinase using PROTAC-mediated degradation. Biochemistry 57(26), 3564-3575 (2018).