A DcpS inhibitor
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RG3039

Item No. 36589

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[1-[(2,6-dichlorophenyl)methyl]-4-piperidinyl]methoxy]-2,4-quinazolinediamine
CAS Number
1005504-62-0
Molecular Formula
C21H23Cl2N5O
Formula Weight
432.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
222, 244 nm
SMILES
ClC1=CC=CC(Cl)=C1CN2CCC(CC2)COC3=C4C(N)=NC(N)=NC4=CC=C3
InChi Code
InChI=1S/C21H23Cl2N5O/c22-15-3-1-4-16(23)14(15)11-28-9-7-13(8-10-28)12-29-18-6-2-5-17-19(18)20(24)27-21(25)26-17/h1-6,13H,7-12H2,(H4,24,25,26,27)
InChi Key
MNLHFGXIUJNDAF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $99

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    10 mg

    $181

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    25 mg

    $404

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    Product Description

    RG3039 is an inhibitor of mRNA decapping scavenger enzyme (DcpS; IC50 = 0.069 nM).1 It prevents denervation of the neuromuscular junction (NMJ) and decreases in NMJ synaptic transmission and myofiber size of the longissimus muscle in a mouse model of spinal muscular atrophy (SMA) induced by knockout of the gene encoding survival motor neuron 1 (Smn1) when administered at a dose of 10 mg/kg.2 RG3039 improves survival and motor function in the same model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gopalsamy, A., Narayanan, A., Liu, S., et al. Design of potent mRNA decapping scavenger enzyme (DcpS) inhibitors with improved physicochemical properties to investigate the mechanism of therapeutic benefit in spinal muscular atrophy (SMA). J. Med. Chem. 60(7), 3094-3108 (2017).

    2. Van Meerbeke, J.P., Gibbs, R.M., Plasterer, H.L., et al. The DcpS inhibitor RG3039 improves motor function in SMA mice. Hum. Mol. Genet. 22(20), 4074-4083 (2013).