A GAL2 receptor positive allosteric modulator
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CYM 2503

Item No. 36590

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-cyclohexyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-N-(1,2-dihydro-4-methyl-2-oxo-7-quinolinyl)-N6-[(1,1-dimethylethoxy)carbonyl]-L-lysinamide
CAS Number
1308833-36-4
Molecular Formula
C45H55N5O7
Formula Weight
778.0
Purity
≥95%
Formulation
A solid
SMILES
CC(C1=CC=C(C=C1N2)NC([C@H](CCCCNC(OC(C)(C)C)=O)NC([C@H](CC3CCCCC3)NC(OCC4C5=CC=CC=C5C6=CC=CC=C64)=O)=O)=O)=CC2=O
InChi Code
InChI=1S/C45H55N5O7/c1-28-24-40(51)48-38-26-30(21-22-31(28)38)47-41(52)37(20-12-13-23-46-43(54)57-45(2,3)4)49-42(53)39(25-29-14-6-5-7-15-29)50-44(55)56-27-36-34-18-10-8-16-32(34)33-17-9-11-19-35(33)36/h8-11,16-19,21-22,24,26,29,36-37,39H,5-7,12-15,20,23,25,27H2,1-4H3,(H,46,54)(H,47,52)(H,48,51)(H,49,53)(H,50,55)/t37-,39-/m0/s1
InChi Key
BSFFWLJHCCBOPN-QARUCVQPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $158

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    10 mg

    $275

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    25 mg

    $590

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    Product Description

    CYM 2503 is a positive allosteric modulator (PAM) of the galanin-2 (GAL2) receptor.1 It enhances the production of inositol monophosphate (IP1) induced by galanin in HEK293 cells expressing the GAL2 receptor (EC50 = 0.69 µM). CYM 2503 (60 mg/kg) increases the latency to first electrographic and behavioral seizures and reduces mortality in a lithium-pilocarpine (Li-pilocarpine) rat model of status epilepticus.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lu, X., Roberts, E., Xia, F., et al. GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models. Proc. Natl. Acad. Sci. USA 107(34), 15229-15234 (2010).